Transgender Male to Female Hormone Therapy. What to Expect Dr. Estrogen Hormone Therapy is a possible way to transition from a male to a female. People want the changes from hormone therapy to happen rapidly, but there are some expectations, long-term considerations, medications, and other factors that need to be understood. Pores produce less oil and become smaller. You may notice that you develop cuts or bruises more often and the odor from your urine and sweat change. You may sweat less as well. You may experience temperature and pain differently due to a difference in touch. Touching them may result in slight pain, and they can also look uneven.
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